Epigenetic Inheritance and Reprogramming During Mammalian Early Development 求真講壇 第十二期

發布時間 :2019-11-18  閱讀次數 :3190

講座時間:2019112010:00-11:30

講座地點:上海交通大學閔行校區生物藥學樓樹華報告廳

主 講 人:清華大學生命科學學院研究員 頡偉

主辦單位:生命科學技術學院

人:邢海娜 (xinghaina@sjtu.edu.cn)

 

               

 

主講人簡介:

頡偉教授2003年畢業于北京大學生命科學學院,2008年在UCLA美國科學院院士Michael Grunstein實驗室完成了分子生物學的博士以及統計學碩士的雙學位學習。之后在 UCSD任兵教授實驗室完成了博士后工作。2013年加入清華大學生命科學學院任研究員,同時加入清華——北大生命科學聯合中心。

頡偉教授自2013年全職來到清華大學工作以來,主要以小鼠和胚胎干細胞為模式系統,應用分子生物學、基因組學和計算生物學,研究配子和早期胚胎細胞命運與發育的調控機制。取得了一系列重要的科研進展,最早在DNA水平闡明哺乳動物生命起始時期染色體動態調控以及組蛋白修飾的世代間遺傳問題。共發表高水平論文40余篇,包括以通訊作者在 Nature(4篇),Science(1篇),Nat Genet(2篇),Mol Cell(4篇)等國際重要刊物上發表論文,同時應邀在Trends in Cell Biology和 Nature Reviews撰寫綜述。由于這些成果,頡偉獲得基金委杰出青年基金,香港求是杰出青年學者,談家楨生命科學創新獎,中源協和生命科學創新獎,樹蘭醫學青年獎,中國青年科技獎等榮譽,并于2017年入選美國霍華德休斯頓研究院的國際學者。

 

內容簡介:

Drastic epigenetic reprogramming occurs during mammalian early embryogenesis. Deciphering the molecular events underlying these processes is crucial for understanding how epigenetic information is transmitted between generations and how life really begins. Probing these questions was previously hindered by the scarce experimental materials that are available in early development. By developing a set of ultra-sensitive chromatin analysis technologies, we investigated chromatin reprogramming during early mouse development for chromatin accessibility, histone modifications, and 3D architecture. These studies unveiled highly dynamic and non-canonical chromatin regulation during maternal-to-zygotic transition and zygotic genome activation. Recently, we further showed how the oocyte epigenome is established through extensive cross talks of chromatin modifications, and how its defects exert a profound impact on embryonic development. Finally, I will also discuss how chromatin reprogramming occurs in other species including humans. Comparison among different species reveals both conservation and divergence during evolution in the molecular principles underlying epigenetic inheritance and reprogramming between generations.

 

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